알림마당
세미나/취업안내
[BK 특별 세미나] UC David 김진환 교수님
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｜2025.01.08
2025년 BK정밀 특별세미나
2025. 1. 15. (수) 10:30 ~ 11:30 | 하나과학관 B동 452호 세미나실
연사 : Prof. Jinhwan Kim (김진환)
언제 : Non-invasive, real-time tracking of cell-based therapies
소속: University of California, Davis Biomedical Engineering
홈페이지: https://bme.ucdavis.edu/people/jinhwan-kim
호스트: 바이오의공학부 정아람
후원: 고려대학교 4단계 BK21 정밀보건과학교육연구단
초록: Recent advancements in nanomedicine have shown the potential of the integration of nanomaterials with endogenous cells to enhance therapeutic delivery and overcome biological barriers. By functionalizing therapeutic cells with nanoparticles, these cells acquire unique physicochemical properties that allow real-time tracking and manipulation. Ultrasound-guided photoacoustic (US/PA) imaging represents a promising technique for in vivo monitoring of these nanoengineered cells. This dual-modality approach combines the deep tissue penetration of ultrasound with the high spatial resolution of photoacoustic imaging, enabling precise visualization of injected cells. Nanoparticles enhance the optical contrast for photoacoustic signals, while ultrasound provides anatomical guidance, facilitating the accurate monitoring of cell distribution and behavior. Additionally, this approach allows for controlling cell functions, offering a novel strategy to improve the efficacy and safety of cell-based therapies. In this presentation, we will discuss two examples demonstrating how the integration of functional nanoparticles with therapeutic cells can advance T cell-based and natural killer (NK) cell-based cancer immunotherapies. Our findings reveal that nanoengineered T and NK cells can be successfully detected in vivo at pre-clinical injection doses and can serve as predictors of cancer immunotherapy success by ensuring the initial infiltration of these cells into tumor masses.
2025. 1. 15. (수) 10:30 ~ 11:30 | 하나과학관 B동 452호 세미나실
연사 : Prof. Jinhwan Kim (김진환)
언제 : Non-invasive, real-time tracking of cell-based therapies
소속: University of California, Davis Biomedical Engineering
홈페이지: https://bme.ucdavis.edu/people/jinhwan-kim
호스트: 바이오의공학부 정아람
후원: 고려대학교 4단계 BK21 정밀보건과학교육연구단
초록: Recent advancements in nanomedicine have shown the potential of the integration of nanomaterials with endogenous cells to enhance therapeutic delivery and overcome biological barriers. By functionalizing therapeutic cells with nanoparticles, these cells acquire unique physicochemical properties that allow real-time tracking and manipulation. Ultrasound-guided photoacoustic (US/PA) imaging represents a promising technique for in vivo monitoring of these nanoengineered cells. This dual-modality approach combines the deep tissue penetration of ultrasound with the high spatial resolution of photoacoustic imaging, enabling precise visualization of injected cells. Nanoparticles enhance the optical contrast for photoacoustic signals, while ultrasound provides anatomical guidance, facilitating the accurate monitoring of cell distribution and behavior. Additionally, this approach allows for controlling cell functions, offering a novel strategy to improve the efficacy and safety of cell-based therapies. In this presentation, we will discuss two examples demonstrating how the integration of functional nanoparticles with therapeutic cells can advance T cell-based and natural killer (NK) cell-based cancer immunotherapies. Our findings reveal that nanoengineered T and NK cells can be successfully detected in vivo at pre-clinical injection doses and can serve as predictors of cancer immunotherapy success by ensuring the initial infiltration of these cells into tumor masses.
