2025년 BK정밀 특별세미나 
2025. 2. 21. (금) 14:00 ~ 15:00 | 하나과학관 B동 452호 세미나실

연사 : Prof. Hirofumi Shintaku
언제 : Nano-electrokinetic transcriptomics empowers the phenotyping of single cells
소속: Kyoto University
호스트: 바이오의공학부 정아람
후원: 고려대학교 4단계 BK21 정밀보건과학교육연구단

초록: Nanopore electroporation uses nanoscale structures to create focused electric fields, which form pores in lipid bilayers with low invasiveness. We here discuss the biophysics of the pore formation that depends on the cell surface tension and introduce an approach that leverages nanopore electroporation and single-cell RNA-sequencing to parallelly profile cell surface tension and gene expression. We show that our system dissects the heterogeneity in cellular mechanics and uncovers the regulatory mechanism in cancer malignancy, cell differentiation, and cellular senescence.